Droplet digital polymerase chain reaction for DNMT3A and IDH1/2 mutations to improve early detection of acute myeloid leukemia relapse after allogeneic hematopoietic stem cell transplantation

Haematologica. 2016 Apr;101(4):e157-61. doi: 10.3324/haematol.2015.135467. Epub 2015 Dec 24.
No abstract available

Keywords: acute myeloid leukemia; cytogenetics and molecular genetics; droplet digital PCR; minimal residual disease; stem cell transplantation.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Alleles
  • Biomarkers, Tumor / genetics*
  • Biomarkers, Tumor / metabolism
  • DNA (Cytosine-5-)-Methyltransferases / genetics*
  • DNA (Cytosine-5-)-Methyltransferases / metabolism
  • DNA Methyltransferase 3A
  • Early Diagnosis
  • Female
  • Gene Expression
  • Gene Frequency
  • Hematopoietic Stem Cell Transplantation*
  • Humans
  • Isocitrate Dehydrogenase / genetics*
  • Isocitrate Dehydrogenase / metabolism
  • Leukemia, Myeloid, Acute / diagnosis*
  • Leukemia, Myeloid, Acute / genetics
  • Leukemia, Myeloid, Acute / pathology
  • Leukemia, Myeloid, Acute / therapy
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Mutation
  • Neoplasm, Residual
  • Polymerase Chain Reaction / instrumentation
  • Polymerase Chain Reaction / methods*
  • Recurrence
  • Transplantation, Homologous

Substances

  • Biomarkers, Tumor
  • DNMT3A protein, human
  • IDH2 protein, human
  • Isocitrate Dehydrogenase
  • IDH1 protein, human
  • DNA (Cytosine-5-)-Methyltransferases
  • DNA Methyltransferase 3A