Reflectin as a Material for Neural Stem Cell Growth

ACS Appl Mater Interfaces. 2016 Jan 13;8(1):278-84. doi: 10.1021/acsami.5b08717. Epub 2015 Dec 24.

Abstract

Cephalopods possess remarkable camouflage capabilities, which are enabled by their complex skin structure and sophisticated nervous system. Such unique characteristics have in turn inspired the design of novel functional materials and devices. Within this context, recent studies have focused on investigating the self-assembly, optical, and electrical properties of reflectin, a protein that plays a key role in cephalopod structural coloration. Herein, we report the discovery that reflectin constitutes an effective material for the growth of human neural stem/progenitor cells. Our findings may hold relevance both for understanding cephalopod embryogenesis and for developing improved protein-based bioelectronic devices.

Keywords: bioelectronics; biointerfaces; cephalopods; reflectin; stem cells.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Astrocytes / cytology
  • Astrocytes / drug effects
  • Biocompatible Materials / pharmacology*
  • Cell Differentiation / drug effects
  • Cell Line
  • Cell Proliferation / drug effects
  • Decapodiformes / chemistry
  • Humans
  • Microscopy, Fluorescence
  • Neural Stem Cells / cytology*
  • Neural Stem Cells / drug effects
  • Neurons / cytology
  • Neurons / drug effects
  • Proteins / pharmacology*

Substances

  • Biocompatible Materials
  • Proteins