Guignardones P-S, New Meroterpenoids from the Endophytic Fungus Guignardia mangiferae A348 Derived from the Medicinal Plant Smilax glabra

Molecules. 2015 Dec 21;20(12):22900-7. doi: 10.3390/molecules201219890.

Abstract

Four new meroterpenoids, guignardones P-S (1-4), and three known analogues (5-7) were isolated from the endophytic fungal strain Guignardia mangiferae A348. Their structures were elucidated on the basis of spectroscopic analysis and single crystal X-ray diffraction. All the isolated compounds were evaluated for their inhibitory effects on SF-268, MCF-7, and NCI-H460 human cancer cell lines. Compounds 2 and 4 exhibited weak inhibitions of cell proliferation against MCF-7 cell line.

Keywords: Guignardia mangiferae; Smilax glabra; endophytic fungus; meroterpenoids; structure identification.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Ascomycota / chemistry*
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Crystallography, X-Ray / methods
  • Humans
  • MCF-7 Cells
  • Mangifera / chemistry*
  • Plants, Medicinal / chemistry
  • Plants, Medicinal / microbiology*
  • Smilax / chemistry
  • Smilax / microbiology*
  • Terpenes / chemistry*
  • Terpenes / pharmacology
  • X-Ray Diffraction / methods

Substances

  • Terpenes