The elusive endogenous adipogenic PPARγ agonists: Lining up the suspects

Philip Hallenborg; Rasmus K Petersen; Irene Kouskoumvekaki; John W Newman; Lise Madsen; Karsten Kristiansen

doi:10.1016/j.plipres.2015.11.002

The elusive endogenous adipogenic PPARγ agonists: Lining up the suspects

Prog Lipid Res. 2016 Jan:61:149-62. doi: 10.1016/j.plipres.2015.11.002. Epub 2015 Dec 15.

Authors

Philip Hallenborg¹, Rasmus K Petersen², Irene Kouskoumvekaki³, John W Newman⁴, Lise Madsen⁵, Karsten Kristiansen⁶

Affiliations

¹ Laboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, 2100 Copenhagen Ø, Denmark; Department of Biochemistry, University of Southern Denmark, 5230 Odense M, Denmark.
² Laboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, 2100 Copenhagen Ø, Denmark.
³ Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, 2800 Kongens Lyngby, Denmark.
⁴ Obesity and Metabolism Research Unit, United States Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research Center, USA; Department of Nutrition, University of California Davis, Davis, CA 95695, USA.
⁵ Laboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, 2100 Copenhagen Ø, Denmark; National Institute of Nutrition and Seafood Research, Postboks 2029, Nordnes, N-5817 Bergen, Norway.
⁶ Laboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, 2100 Copenhagen Ø, Denmark. Electronic address: kk@bio.ku.dk.

PMID: 26703188
DOI: 10.1016/j.plipres.2015.11.002

Abstract

The nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ) is the key decisive factor controlling the development of adipocytes. Ligand-mediated activation of PPARγ occurs early during adipogenesis and is thought to prime adipose conversion. Although several fatty acids and their derivatives are known to bind to and activate PPARγ, the identity of the ligand(s) responsible for initiating adipocyte differentiation is still a matter of debate. Here we review recent data on pathways involved in ligand production as well as possible endogenous, adipogenic PPARγ agonists.

Keywords: Adipogenesis; Cyclooxygenases; Lipoxygenases; PPARγ; Polyunsaturated fatty acids; Reactive oxygen species.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Adipocytes / physiology
Adipogenesis*
Animals
Fatty Acids / metabolism
Humans
Lipid Metabolism
Oxidation-Reduction
PPAR gamma / physiology*
Prostaglandins

Substances

Fatty Acids
PPAR gamma
Prostaglandins