Red-Light-Responsive Supramolecular Valves for Photocontrolled Drug Release from Mesoporous Nanoparticles

Langmuir. 2016 Jan 19;32(2):632-6. doi: 10.1021/acs.langmuir.5b04399. Epub 2016 Jan 5.

Abstract

Red-light-responsive supramolecular valves constructed by tetra-ortho-methoxy-substituted azobenzene (mAzo) and β-cyclodextrin (β-CD) were used to control drug release from mesoporous silica nanoparticles (MSNs). Doxorubicin (DOX) was used as a model drug and loaded into nanopores of mAzo modified MSNs. β-CD formed supramolecular valves with mAzo by host-guest interaction and closed the nanopores. Red light was able to open the supramolecular valves and induce DOX release even in deep tissue.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Azo Compounds / chemistry*
  • Delayed-Action Preparations / chemistry*
  • Doxorubicin / chemistry*
  • Drug Compounding
  • Drug Liberation
  • Hydrogen-Ion Concentration
  • Light
  • Nanoparticles / chemistry*
  • Nanoparticles / ultrastructure
  • Nanopores / ultrastructure
  • Porosity
  • Silicon Dioxide / chemistry
  • beta-Cyclodextrins / chemistry*

Substances

  • Azo Compounds
  • Delayed-Action Preparations
  • beta-Cyclodextrins
  • Silicon Dioxide
  • Doxorubicin
  • azobenzene
  • betadex