Are Astrocytes the Pressure-Reservoirs of Lactate in the Brain?

Cell Metab. 2016 Jan 12;23(1):1-2. doi: 10.1016/j.cmet.2015.11.001. Epub 2015 Nov 19.

Abstract

The role of lactate in the brain has been controversial. In this issue, Mächler et al. (2015) present data from in vivo experiments suggesting that there is a downward gradient of lactate in the brain. They provide a mechanistic basis for the proposed export of lactate from astrocytes to neurons.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Astrocytes*
  • Brain
  • Lactic Acid*
  • Neurons

Substances

  • Lactic Acid