Can Breast Tumors Affect the Oxidative Status of the Surrounding Environment? A Comparative Analysis among Cancerous Breast, Mammary Adjacent Tissue, and Plasma

Oxid Med Cell Longev. 2015:2015:6429812. doi: 10.1155/2016/6429812. Epub 2015 Nov 30.

Abstract

In this paper, we investigated the oxidative profile of breast tumors in comparison with their normal adjacent breast tissue. Our study indicates that breast tumors present enhanced oxidative/nitrosative stress, with concomitant augmented antioxidant capacity when compared to the adjacent normal breast. These data indicate that breast cancers may be responsible for the induction of a prooxidant environment in the mammary gland, in association with enhanced TNF-α and nitric oxide.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Area Under Curve
  • Breast / metabolism
  • Breast / pathology*
  • Breast Neoplasms / metabolism
  • Breast Neoplasms / pathology*
  • Chromatography, High Pressure Liquid
  • Female
  • Homocysteine / analysis
  • Humans
  • Lipid Peroxidation
  • Malondialdehyde / analysis
  • Mammary Glands, Human / metabolism
  • Mammary Glands, Human / pathology*
  • Middle Aged
  • Nitric Oxide / analysis
  • Oxidative Stress*
  • Protein Carbonylation
  • ROC Curve
  • Tumor Necrosis Factor-alpha / analysis

Substances

  • Tumor Necrosis Factor-alpha
  • Homocysteine
  • Nitric Oxide
  • Malondialdehyde