The evolving potential for pediatric ex vivo lung perfusion

Pediatr Transplant. 2016 Feb;20(1):13-22. doi: 10.1111/petr.12653. Epub 2015 Dec 23.

Abstract

Despite the rise in the number of adult lung transplantations performed, rates of pediatric lung transplantation remain low. Lung transplantation is an accepted therapy for pediatric end-stage lung disease; however, it is limited by a shortage of donor organs. EVLP has emerged as a platform for assessment and preservation of donor lung function. EVLP has been adopted in adult lung transplantation and has successfully led to increased adult lung transplantations and donor lung utilization. We discuss the future implications of EVLP utilization, specifically, its potential evolving role in overcoming donor shortages in smaller children and adolescents to improve the quality and outcomes of lung transplantation in pediatric patients.

Keywords: allograft function; outcome; pediatric lung transplantation.

Publication types

  • Review

MeSH terms

  • Adolescent
  • Adult
  • Child
  • Cystic Fibrosis / surgery
  • Humans
  • Lung / physiology*
  • Lung Diseases / mortality
  • Lung Diseases / surgery*
  • Lung Transplantation / methods*
  • Organ Size
  • Oxygen
  • Perfusion / methods*
  • Respiratory Function Tests
  • Tissue Donors / supply & distribution
  • Tissue and Organ Procurement / methods
  • Treatment Outcome
  • Waiting Lists

Substances

  • Oxygen