miR-506 inhibits the proliferation and invasion by targeting IGF2BP1 in glioblastoma

Yonggang Luo; Ranran Sun; Jun Zhang; Tongwen Sun; Xianzhi Liu; Bo Yang

miR-506 inhibits the proliferation and invasion by targeting IGF2BP1 in glioblastoma

Am J Transl Res. 2015 Oct 15;7(10):2007-14. eCollection 2015.

Authors

Yonggang Luo¹, Ranran Sun², Jun Zhang³, Tongwen Sun¹, Xianzhi Liu⁴, Bo Yang⁴

Affiliations

¹ Department of Intensive Care Unit, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450000, Henan, China.
² Department of Infectious Disease, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450000, Henan, China.
³ Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450000, Henan, China.
⁴ Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450000, Henan, China.

PMID: 26692944
PMCID: PMC4656777

Abstract

Increasing evidence has indicated that microRNAs (miRNAs) play an essential role in cancers. Deregulation of miR-506 was reported in several cancers. However, the expression and function of miR-506 in glioblastoma remain unclear. Our data showed that the level of miR-506 was downregulated in glioblastoma tissues and cell lines. Overexpression of miR-506 repressed cell growth, blocked G1/S transition, and suppressed cell invasion in glioblastoma cell. Moreover, IGF2BP1 was a direct target of miR-506 in glioblastoma cells. Knockdown of IGF2BP1 recapitulated the anti-proliferative and anti-invasive effects of miR-506, whereas IGF2BP1 overexpression antagonized the tumor-suppressive function of miR-506. Our data showed that miRNA-506 played a tumor suppressor gene role in human glioblastoma by regulating IGF2BP1 gene and might be a new therapeutic target of human glioblastoma.

Keywords: Glioblastoma; IGF2BP1; miR-506; miRNA.