Abstract
A series of new zinc compounds has been prepared easily under mild synthetic conditions with the drug ibuprofen incorporated as a ligand to form different coordination polymers. The host materials have a high drug content and exhibit high stability, low cytotoxicity, good biodegradability and high biocompatibility. The ion exchange mechanism involved in the ibuprofen release process and the pH-controlled drug release have been studied.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Cell Proliferation / drug effects
-
Crystallography, X-Ray
-
Dose-Response Relationship, Drug
-
Drug Stability
-
Humans
-
Hydrogen-Ion Concentration
-
Ibuprofen / chemistry*
-
Models, Molecular
-
Organometallic Compounds / chemical synthesis
-
Organometallic Compounds / chemistry
-
Organometallic Compounds / pharmacology*
-
Particle Size
-
Polymers / chemical synthesis
-
Polymers / chemistry
-
Polymers / pharmacology*
-
Structure-Activity Relationship
-
Surface Properties
-
Zinc / chemistry
-
Zinc / pharmacology*
Substances
-
Organometallic Compounds
-
Polymers
-
Zinc
-
Ibuprofen