Mitochondrial Delivery of Therapeutic Agents by Amphiphilic DNA Nanocarriers

Small. 2016 Feb 10;12(6):770-81. doi: 10.1002/smll.201503051. Epub 2015 Dec 21.

Abstract

The first example of mitochondrial delivery of the anticancer drug doxorubicin (Dox) is presented by lipid-functionalized DNA nanocages (LNCs). Dox localized in mitochondria induces significant cytotoxicity and cellular apoptosis in MCF-7 compared with Dox localized in lysosomes. These results suggest that LNC has the potential to be an outstanding tool in the treatment of specific organelle-related diseases such as cancers.

Keywords: DNA nanocarriers; anticancer drugs; delivery; lipophilic molecules; mitochondria.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carbazoles / chemistry
  • DNA / metabolism
  • Doxorubicin / pharmacology*
  • Drug Carriers / chemistry*
  • Endocytosis / drug effects
  • HeLa Cells
  • Humans
  • Lipids / chemistry
  • MCF-7 Cells
  • Mitochondria / drug effects
  • Mitochondria / metabolism*
  • Nanoparticles / chemistry*
  • Native Polyacrylamide Gel Electrophoresis
  • Surface-Active Agents / chemistry*

Substances

  • Carbazoles
  • Drug Carriers
  • Lipids
  • Surface-Active Agents
  • Doxorubicin
  • DNA