Genetic characterization of highly pathogenic H5 influenza viruses from poultry in Taiwan, 2015

Pei-Yu Huang; Chang-Chun David Lee; Chun-Hung Yip; Chung-Lam Cheung; Guangchuang Yu; Tommy Tsan-Yuk Lam; David K Smith; Huachen Zhu; Yi Guan

doi:10.1016/j.meegid.2015.12.006

Genetic characterization of highly pathogenic H5 influenza viruses from poultry in Taiwan, 2015

Infect Genet Evol. 2016 Mar:38:96-100. doi: 10.1016/j.meegid.2015.12.006. Epub 2015 Dec 10.

Authors

Pei-Yu Huang¹, Chang-Chun David Lee², Chun-Hung Yip³, Chung-Lam Cheung⁴, Guangchuang Yu⁴, Tommy Tsan-Yuk Lam⁴, David K Smith⁴, Huachen Zhu⁵, Yi Guan⁶

Affiliations

¹ Joint Influenza Research Centre, Shantou University Medical College, Shantou, Guangdong, China; Centre of Influenza Research, School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region.
² Genomics Research Center, Academia Sinica, Taipei, Taiwan.
³ Centre of Influenza Research, School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region; State Key Laboratory of Emerging Infectious Diseases (Shenzhen Base), Shenzhen Third People's Hospital, Shenzhen, China.
⁴ Centre of Influenza Research, School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region.
⁵ Joint Influenza Research Centre, Shantou University Medical College, Shantou, Guangdong, China; Centre of Influenza Research, School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region; State Key Laboratory of Emerging Infectious Diseases (Shenzhen Base), Shenzhen Third People's Hospital, Shenzhen, China. Electronic address: zhuhch@hku.hk.
⁶ Joint Influenza Research Centre, Shantou University Medical College, Shantou, Guangdong, China; Centre of Influenza Research, School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region; State Key Laboratory of Emerging Infectious Diseases (Shenzhen Base), Shenzhen Third People's Hospital, Shenzhen, China. Electronic address: yguan@hku.hk.

PMID: 26690663
DOI: 10.1016/j.meegid.2015.12.006

Abstract

Phylogenetic analysis of the highly pathogenic avian influenza (HPAI) H5 viruses causing recent outbreaks in Taiwan showed that they belonged to the Asian HPAI H5 lineage, clade 2.3.4.4 viruses, and were apparently introduced by migratory birds. These viruses reassorted with Eurasian influenza gene pool viruses and formed five genotypic variants. As Taiwan has a similar influenza ecosystem to southern China, the HPAI H5 lineage could become established and enzootic in the island.

Keywords: Clade 2.3.4.4; Eurasian gene pool; Genotype; H5N8; Migratory bird; Reassortment.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Genes, Viral
Genotype
Geography, Medical
Influenza A virus / classification*
Influenza A virus / genetics*
Influenza in Birds / epidemiology
Influenza in Birds / virology*
Phylogeny
Phylogeography
Poultry
Taiwan / epidemiology

Grants and funding

HHSN272201400006C/PHS HHS/United States