Development of Highly Functional Biomaterials by Decoupling and Recombining Material Properties

Adv Mater. 2016 Mar 2;28(9):1803-8. doi: 10.1002/adma.201504589. Epub 2015 Dec 22.

Abstract

Development of functional biomaterials by a design-driven approach is described, whereby individual properties are first decoupled to investigate their sole effects on a biological process. Following this investigation, they are recombined in such a way that the overall performance and applicability of the biomaterial is improved. This is in contrast to classical, processing-driven biomaterials development where the properties of a material are mainly determined by the possibilities of the technique used to produce it.

Keywords: calcium phosphates; composites; nanoimprinting; osteogenic differentiation; property-function relationships.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biocompatible Materials / chemistry*
  • Biocompatible Materials / pharmacology*
  • Bone Morphogenetic Protein 2 / genetics
  • Calcium Phosphates / chemistry
  • Drug Design
  • Elastomers / chemistry
  • Gene Expression Regulation / drug effects
  • Humans
  • Mesenchymal Stem Cells / drug effects
  • Mesenchymal Stem Cells / metabolism
  • Models, Molecular
  • Molecular Conformation
  • Osteopontin / genetics
  • Surface Properties

Substances

  • BMP2 protein, human
  • Biocompatible Materials
  • Bone Morphogenetic Protein 2
  • Calcium Phosphates
  • Elastomers
  • Osteopontin
  • calcium phosphate