Endogenous DNA Damage and Repair Enzymes: -A short summary of the scientific achievements of Tomas Lindahl, Nobel Laureate in Chemistry 2015

Arne Klungland; Yun-Gui Yang

doi:10.1016/j.gpb.2015.11.001

Endogenous DNA Damage and Repair Enzymes: -A short summary of the scientific achievements of Tomas Lindahl, Nobel Laureate in Chemistry 2015

Genomics Proteomics Bioinformatics. 2016 Jun;14(3):122-125. doi: 10.1016/j.gpb.2015.11.001. Epub 2015 Dec 12.

Authors

Arne Klungland¹, Yun-Gui Yang²

Affiliations

¹ Department of Microbiology, Division of Diagnostics and Intervention, Institute of Clinical Medicine, Oslo University Hospital, Rikshospitalet, Oslo NO-0027, Norway; Department of Molecular Medicine, Faculty of Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo NO-0027, Norway. Electronic address: arne.klungland@medisin.uio.no.
² CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China. Electronic address: ygyang@big.ac.cn.

Abstract

Tomas Lindahl completed his medical studies at Karolinska Institute in 1970. Yet, his work has always been dedicated to unraveling fundamental mechanisms of DNA decay and DNA repair. His research is characterized with groundbreaking discoveries on the instability of our genome, the identification of novel DNA repair activities, the characterization of DNA repair pathways, and the association to diseases, throughout his 40 years of scientific career.

MeSH terms

DNA / metabolism
DNA Damage*
DNA Repair
DNA Repair Enzymes / metabolism*
Genome, Viral
Herpesvirus 4, Human / genetics
Humans
Nobel Prize

Substances

DNA
DNA Repair Enzymes