Leucocontextins A-R, lanostane-type triterpenoids from Ganoderma leucocontextum

Zhen-Zhu Zhao; He-Ping Chen; Zheng-Hui Li; Ze-Jun Dong; Xue Bai; Zhong-Yu Zhou; Tao Feng; Ji-Kai Liu

doi:10.1016/j.fitote.2015.12.004

Leucocontextins A-R, lanostane-type triterpenoids from Ganoderma leucocontextum

Fitoterapia. 2016 Mar:109:91-8. doi: 10.1016/j.fitote.2015.12.004. Epub 2015 Dec 12.

Authors

Zhen-Zhu Zhao¹, He-Ping Chen¹, Zheng-Hui Li², Ze-Jun Dong³, Xue Bai³, Zhong-Yu Zhou⁴, Tao Feng⁵, Ji-Kai Liu⁶

Affiliations

¹ State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; University of Chinese Academy of Sciences, Beijing 100049, China.
² School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China.
³ State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
⁴ Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China.
⁵ School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China. Electronic address: tfeng@mail.scuec.edu.cn.
⁶ State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China. Electronic address: jkliu@mail.kib.ac.cn.

PMID: 26687559
DOI: 10.1016/j.fitote.2015.12.004

Abstract

Eighteen new lanostane-type triterpenoids, namely leucocontextins A-R (1-18) were isolated from the fruiting bodies of Ganoderma leucocontextum. Their structures were established by 1D and 2D NMR data in conjunction with HRESIMS/HREIMS, X-ray single crystal diffraction analysis. Compound 18 exhibited weak cytotoxicity against K562 and MCF-7 cell lines with IC50 of 20-30 μM.

Keywords: Cytotoxicity; Ganoderma leucocontextum; Triterpenoids.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Fruiting Bodies, Fungal / chemistry
Ganoderma / chemistry*
Humans
K562 Cells
MCF-7 Cells
Molecular Structure
Triterpenes / chemistry*
Triterpenes / isolation & purification

Substances

Triterpenes
leucocontextin R