Oleanane type saponins from the stems of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao

Fitoterapia. 2016 Mar:109:99-105. doi: 10.1016/j.fitote.2015.12.006. Epub 2015 Dec 11.

Abstract

Astragalus membranaceus is a Traditional Chinese Medicine (TCM) belonging to the Leguminosae family. It has been used as antidiabetic, cardioprotective, and hepatoprotective in the TCM clinic. From the stems of A. membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao, 14 oleanane type saponins (1-14) including eight new ones, astroolesaponins A (1), B (2), C1 (3), C2 (4), D (5), E1 (6), E2 (7), and F (8) were obtained, and their structures were elucidated by chemical and spectroscopic methods. Compounds 1-5, 7, 8, 11, and 13 showed decreased effects on triglyceride levels in sodium oleate induced HepG2 cells.

Keywords: Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao; HepG2 cells; Oleanane type; Saponin; Stem; Triglyceride accumulation inhibitory effects.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Astragalus propinquus / chemistry*
  • Hep G2 Cells
  • Humans
  • Molecular Structure
  • Oleanolic Acid / analogs & derivatives*
  • Oleanolic Acid / chemistry
  • Oleanolic Acid / isolation & purification
  • Plants, Medicinal / chemistry
  • Saponins / chemistry*
  • Saponins / isolation & purification

Substances

  • Saponins
  • oleanane
  • Oleanolic Acid