A Stepping Stone to Pluripotency

Hitoshi Niwa

doi:10.1016/j.cell.2015.12.011

A Stepping Stone to Pluripotency

Cell. 2015 Dec 17;163(7):1570-2. doi: 10.1016/j.cell.2015.12.011.

Author

Hitoshi Niwa¹

Affiliation

¹ Department of Pluripotent Stem Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto, 860-0811, Japan. Electronic address: niwa@kumamoto-u.ac.jp.

PMID: 26687348
DOI: 10.1016/j.cell.2015.12.011

Abstract

Somatic cells can be reprogrammed into pluripotent stem cells via either expression of transcription factors or addition of small molecule chemicals only. Zhao et al. reveal a unique intermediate state during chemical reprogramming allowing a significant improvement in its efficiency and kinetics.

Publication types

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MeSH terms

Animals
Cellular Reprogramming Techniques*
Pluripotent Stem Cells / cytology*