Not All Created Equal: Lineage Hard-Wiring in the Production of Blood

Francois E Mercier; David T Scadden

doi:10.1016/j.cell.2015.12.013

Not All Created Equal: Lineage Hard-Wiring in the Production of Blood

Cell. 2015 Dec 17;163(7):1568-70. doi: 10.1016/j.cell.2015.12.013.

Authors

Francois E Mercier¹, David T Scadden²

Affiliations

¹ Center for Regenerative Medicine and Cancer Center, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA; Harvard Stem Cell Institute and Harvard University Department of Stem Cell and Regenerative Biology, 7 Divinity Avenue, Cambridge, MA 02138, USA.
² Center for Regenerative Medicine and Cancer Center, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA; Harvard Stem Cell Institute and Harvard University Department of Stem Cell and Regenerative Biology, 7 Divinity Avenue, Cambridge, MA 02138, USA. Electronic address: david_scadden@harvard.edu.

PMID: 26687347
DOI: 10.1016/j.cell.2015.12.013

Abstract

The multiple cell types comprising blood have been thought to emerge from progenitors with progressively narrower lineage options. New data suggest that lineage fate may be determined earlier than thought and that myeloid progenitor populations are aggregates of individual lineage-restricted cells.

Publication types

Comment

MeSH terms

Animals
Cell Lineage*
Hematopoiesis*
Myeloid Progenitor Cells / cytology*
Myeloid Progenitor Cells / metabolism*
Single-Cell Analysis*
Transcriptome*