Flexible DNA junction assisted efficient construction of stable gene nanoparticles for gene delivery

Jianbing Liu; Yanyan Li; Dejun Ma; Di Ouyang; Zhen Xi

doi:10.1039/c5cc07949g

Flexible DNA junction assisted efficient construction of stable gene nanoparticles for gene delivery

Chem Commun (Camb). 2016 Jan 31;52(9):1953-6. doi: 10.1039/c5cc07949g.

Authors

Jianbing Liu¹, Yanyan Li¹, Dejun Ma¹, Di Ouyang¹, Zhen Xi¹

Affiliation

¹ Department of Chemical Biology, State Key Laboratory of Elemento-Organic Chemistry, National Engineering Research Center of Pesticide (Tianjin), Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, China. zhenxi@nankai.edu.cn.

PMID: 26686591
DOI: 10.1039/c5cc07949g

Abstract

A flexible DNA junction was designed to assist the construction of stable gene nanoparticles with multiple target gene copies, which can be used as efficient gene cargo with successful expression in eukaryotic cells for gene delivery.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

DNA / chemistry*
Gene Transfer Techniques*
Microscopy, Atomic Force
Nanoparticles*

Substances

DNA