Frailty Syndrome in Heart Failure Patients who are Receiving Cardiac Resynchronization

Pacing Clin Electrophysiol. 2016 Apr;39(4):370-4. doi: 10.1111/pace.12800. Epub 2016 Jan 21.

Abstract

Background: We hypothesized that patients with de novo cardiac resynchronization therapy (CRT) implantation had a more intense frailty syndrome when compared to the patients who qualified for a system upgrade.

Methods: One hundred and six patients aged ≥65 years were included. They were divided into two groups: de novo CRT implantation--74 patients and upgrade from standard right heart pacing--32 patients. A CRT was finally implanted in all of the patients. Frailty was evaluated using the Canadian Study of Health and Aging Clinical Frailty Scale (CSHA-CFS).

Results: The average results in CSHA-CFS were statistically higher (5.3 ± 0.8) in the de novo patients when compared to the patients who qualified for a system upgrade (4.9 ± 0.8); P = 0.027. Frailty syndrome was recognized in 81.1% of the patients in the de novo group and in 68.7% of the patients in the upgrade group; P = 0.164. Only one patient of the 106 had no attributes of frailty (or exposed ones) syndrome.

Conclusions: Frailty syndrome is a common phenomenon in patients with heart failure and over 65 years of age. The syndrome is most often recognized in patients who are de novo qualified for cardiac resynchronization.

Keywords: cardiac resynchronization therapy; cardioverter defibrillator; frailty; heart failure; pacemaker.

MeSH terms

  • Age Distribution
  • Aged, 80 and over
  • Cardiac Resynchronization Therapy / statistics & numerical data*
  • Causality
  • Comorbidity
  • Female
  • Frail Elderly / statistics & numerical data*
  • Heart Failure / epidemiology*
  • Heart Failure / prevention & control*
  • Humans
  • Incidence
  • Male
  • Muscle Weakness / diagnosis
  • Muscle Weakness / epidemiology*
  • Poland / epidemiology
  • Risk Factors
  • Sarcopenia / diagnosis
  • Sarcopenia / epidemiology*
  • Sex Distribution
  • Syndrome
  • Treatment Outcome