Getting Tumor Dendritic Cells to Engage the Dead

Lisa Cucolo; Andy J Minn

doi:10.1016/j.ccell.2015.11.009

Getting Tumor Dendritic Cells to Engage the Dead

Cancer Cell. 2015 Dec 14;28(6):685-687. doi: 10.1016/j.ccell.2015.11.009.

Authors

Lisa Cucolo¹, Andy J Minn²

Affiliations

¹ Abramson Family Cancer Research Institute, Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
² Abramson Family Cancer Research Institute, Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: andyminn@mail.med.upenn.edu.

PMID: 26678335
DOI: 10.1016/j.ccell.2015.11.009

Abstract

The immunogenic effects of chemotherapy rely on effective activation of dendritic cells to present antigen to tumor-specific T cells. However, the signals that govern how dendritic cells seek out dying cancer cells to initiate this process are poorly understood. A recent study by Vacchelli et al. provides important insight.

Publication types

Comment

MeSH terms

Animals
Anthracyclines / therapeutic use*
Female
Humans
Neoplasms / drug therapy*
Neoplasms / immunology*
Receptors, Formyl Peptide / physiology*

Substances

Anthracyclines
Receptors, Formyl Peptide