Take It Down a NOTCH in Forebrain Tumors

Cancer Cell. 2015 Dec 14;28(6):681-682. doi: 10.1016/j.ccell.2015.11.008.

Abstract

In this issue of Cancer Cell, Giachino and colleagues, employing various approaches, describe a tumor suppressor function for Notch signaling in forebrain tumors and suggest that decreased Notch activity could be a key molecular event in supratentorial primitive neuroectodermal tumors (sPNET).

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Brain Neoplasms / metabolism*
  • Glioma / metabolism*
  • Humans
  • Neoplastic Stem Cells / metabolism*
  • Neural Stem Cells / metabolism*
  • Prosencephalon / metabolism*
  • Receptors, Notch / metabolism*
  • Signal Transduction*
  • Tumor Suppressor Proteins / metabolism*

Substances

  • Receptors, Notch
  • Tumor Suppressor Proteins