Clinical and Molecular Characterization of Invasive Heteroresistant Vancomycin-Intermediate Staphylococcus aureus Infections in Korean Hospitals

Eu Suk Kim; In-Gyu Bae; Jeong Eun Cho; Yun Jung Choi; Il-Hwan Kim; Gi-Su Kang; Hye-yun Sin; Kyoung-Ho Song; Chulmin Park; Dong-Gun Lee; Moonsuk Kim; Kyoung Un Park; Hong Bin Kim

doi:10.1128/JCM.02595-15

Clinical and Molecular Characterization of Invasive Heteroresistant Vancomycin-Intermediate Staphylococcus aureus Infections in Korean Hospitals

J Clin Microbiol. 2016 Mar;54(3):760-3. doi: 10.1128/JCM.02595-15. Epub 2015 Dec 16.

Authors

Eu Suk Kim¹, In-Gyu Bae², Jeong Eun Cho³, Yun Jung Choi³, Il-Hwan Kim⁴, Gi-Su Kang⁴, Hye-yun Sin³, Kyoung-Ho Song¹, Chulmin Park⁵, Dong-Gun Lee⁶, Moonsuk Kim¹, Kyoung Un Park⁷, Hong Bin Kim⁸

Affiliations

¹ Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.
² Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, South Korea.
³ Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea.
⁴ Division of Antimicrobial Resistance, Center for Infectious Diseases, Korea National Institute of Health, KCDC, Cheongju, South Korea.
⁵ Vaccine Bio Research Institute, The Catholic University of Korea, Seoul, South Korea.
⁶ Vaccine Bio Research Institute, The Catholic University of Korea, Seoul, South Korea Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
⁷ Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, South Korea.
⁸ Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea hbkimmd@snu.ac.kr.

Abstract

Invasive heteroresistant vancomycin-intermediate Staphylococcus aureus (h-VISA) isolates were identified and characterized in 10 Korean hospitals from July 2009 to June 2011. The prevalence of h-VISA infections was 3.3% (42/1,289). Most (41/42) were health care-associated infections caused by strains belonging to sequence type 5. Cases of persistent bacteremia were frequent (17/42), and 30-day mortality was high (16/40).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents / pharmacology
Cross Infection*
Female
Hospitals*
Humans
Male
Microbial Sensitivity Tests
Middle Aged
Republic of Korea / epidemiology
Staphylococcal Infections / diagnosis
Staphylococcal Infections / epidemiology*
Staphylococcal Infections / microbiology*
Staphylococcus aureus / drug effects*
Staphylococcus aureus / genetics*
Vancomycin Resistance*
Young Adult

Substances

Anti-Bacterial Agents