The purpose of the study was to present our experience with endocranial fixation using the Resorb-X mesh (KLS Martin, Jacksonville, FL) in frontoorbital reconstruction. A retrospective review of all patients underwent frontoorbital advancement at our institution from 2003 to 2012 was performed. Inclusion criterion included: pediatric patients who underwent frontoorbital advancement for craniosynostosis; patients underwent treatment of the craniosynostosis only at our center; resorbable fixation devises were applied only endocranially; and follow-up was ≥ 2 years. Patients' evaluation included demographic information, postoperative complications, surgical outcomes, and postoperative computed tomographic imaging if accessible. Thirty-nine patients met the inclusion criteria. Resorbable plates were used in 16 patients and Resorb-X mesh in 23 patients. Observed complications were unrelated to the fixation system used. Resorption of fixation devices was evident in all patients after 20 months following reconstruction. There were no incidents of local reaction to the fixation system. Frontoorbital area contour was deemed good in 24 patients and excellent in 15 patients by both families and attending surgeon. There was a statistical significant difference (P = 0.030) between patients ≤ 12 months and >12 months regarding the complications rate. Endocranial fixation using the Resorb-X mesh is easily applicable, avoids material palpability, and provides stable and secure fixation. This technique is superior to the conventional endocranial osseous fixation with absorbable plates, as it avoids some of its possible complications while providing all the benefits of resorbable fixation.