Isolation of Phomopsolide A and 6(E)-Phomopsolide A as Antimycobacterial Natural Products from an Unidentified Endophyte of the Canadian Medicinal Plant Heracleum maximum

Nat Prod Commun. 2015 Oct;10(10):1647-8.

Abstract

An extract of an unidentified endophyte from the Canadian medicinal plant Heracleum maximum exhibited a unique metabolomic profile and significant antimycobacterial activity against Mycobacterium tuberculosis H37Ra. Bioassay guided fractionation of the extract led to the isolation of phomopsolide A (1) and 6(E)-phomopsolide A (2). This is the first report of antimycobacterial activity for 1 and 2.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antitubercular Agents / chemistry
  • Antitubercular Agents / pharmacology*
  • Biological Products
  • Canada
  • Endophytes / chemistry*
  • Heracleum / chemistry*
  • Molecular Structure
  • Plants, Medicinal / chemistry*
  • Pyrones / chemistry

Substances

  • Antitubercular Agents
  • Biological Products
  • Pyrones
  • phomopsolide A