Circulating resistin is a significant predictor of mortality independently from cardiovascular comorbidities in elderly, non-diabetic subjects with chronic kidney disease

Biomarkers. 2016;21(1):73-9. doi: 10.3109/1354750X.2015.1118536. Epub 2015 Dec 15.

Abstract

Context: Resistin is associated with inflammation, atherosclerosis and cardiovascular (CV) disease.

Objective: To associate circulating resistin with all-cause and CV mortality in chronic kidney disease (CKD) patients.

Methods: Serum resistin was determined in a cohort of 80 elderly, non-diabetic patients with stable CKD at different stages in a follow-up period of 5 years.

Results: Circulating resistin was significantly elevated in deceased compared to alive patients. Resistin emerged as an independent biomarker of all-cause and CV mortality after a 5-year follow-up period.

Conclusion: Elevated circulating resistin was a significant independent predictor of CV and all-cause mortality in elderly, non-diabetic CKD patients.

Keywords: Adipokine; adipose tissue; cytokine; morbidity; renal disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Biomarkers / blood
  • Cardiovascular Diseases / blood*
  • Cardiovascular Diseases / mortality
  • Comorbidity
  • Female
  • Humans
  • Kaplan-Meier Estimate
  • Kidney Failure, Chronic / blood*
  • Kidney Failure, Chronic / mortality
  • Male
  • Middle Aged
  • Prognosis
  • ROC Curve
  • Resistin / blood*

Substances

  • Biomarkers
  • RETN protein, human
  • Resistin