Enhanced target recognition of nanoparticles by cocktail PEGylation with chains of varying lengths

Takehiko Ishii; Kanjiro Miyata; Yasutaka Anraku; Mitsuru Naito; Yu Yi; Takao Jinbo; Seiji Takae; Yu Fukusato; Mao Hori; Kensuke Osada; Kazunori Kataoka

doi:10.1039/c5cc06661a

Enhanced target recognition of nanoparticles by cocktail PEGylation with chains of varying lengths

Chem Commun (Camb). 2016 Jan 25;52(7):1517-9. doi: 10.1039/c5cc06661a.

Authors

Affiliations

¹ Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan. kataoka@bmw.t.u-tokyo.ac.jp.
² Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
³ Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
⁴ Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan. kataoka@bmw.t.u-tokyo.ac.jp and Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

PMID: 26658952
DOI: 10.1039/c5cc06661a

Abstract

Monodispersed gold nanoparticles (AuNPs) were simultaneously decorated with lactosylated and non-modified shorter poly(ethylene glycol)s (PEGs) to enhance their target recognition. The decoration with sufficiently shorter PEGs dramatically enhanced the multivalent binding ability of lactosylated AuNPs to the lectin-fixed surface, possibly due to the enhanced mobility of the ligands via the spacer effect generated by the shorter PEG chains.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Nanoparticles*
Polyethylene Glycols / chemistry

Substances

Polyethylene Glycols