Mucosal IgG Levels Correlate Better with Respiratory Syncytial Virus Load and Inflammation than Plasma IgG Levels

Clin Vaccine Immunol. 2015 Dec 9;23(3):243-5. doi: 10.1128/CVI.00590-15.

Abstract

Maternal vaccination is currently considered a strategy against respiratory syncytial virus (RSV) infections. In RSV-infected infants, high mucosal IgG levels correlated better with reduced RSV load and lower mucosal CXCL10 levels than plasma IgG levels. For future vaccination strategies against RSV, more focus should be on the mucosal humoral immune response.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Viral / blood*
  • Antibodies, Viral / immunology
  • Chemokine CXCL10 / blood*
  • Female
  • Humans
  • Immunity, Maternally-Acquired / immunology*
  • Immunity, Mucosal / immunology*
  • Immunoglobulin A / blood
  • Immunoglobulin G / blood*
  • Infant
  • Male
  • Respiratory Syncytial Virus Infections / immunology
  • Respiratory Syncytial Virus Infections / prevention & control*
  • Respiratory Syncytial Virus, Human / immunology*
  • Viral Vaccines / immunology

Substances

  • Antibodies, Viral
  • CXCL10 protein, human
  • Chemokine CXCL10
  • Immunoglobulin A
  • Immunoglobulin G
  • Viral Vaccines

Grants and funding

Funders had no role in study design, collection, analysis and interpretation of data, the writing of the manuscript or the decision to submit the article for publication.