Filamin A interacting protein plays a role in proper positioning of callosal projection neurons in the cortex

Hideshi Yagi; Yuichiro Oka; Munekazu Komada; Min-Jue Xie; Koichi Noguchi; Makoto Sato

doi:10.1016/j.neulet.2015.11.049

Filamin A interacting protein plays a role in proper positioning of callosal projection neurons in the cortex

Neurosci Lett. 2016 Jan 26:612:18-24. doi: 10.1016/j.neulet.2015.11.049. Epub 2015 Dec 2.

Authors

Hideshi Yagi¹, Yuichiro Oka², Munekazu Komada³, Min-Jue Xie⁴, Koichi Noguchi⁵, Makoto Sato⁶

Affiliations

¹ Division of Cell Biology and Neuroscience, Department of Morphological and Physiological Sciences, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan; Department of Anatomy and Cell Biology, Hyogo College of Medicine, Hyogo 663-8501, Japan.
² Division of Cell Biology and Neuroscience, Department of Morphological and Physiological Sciences, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan; United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Osaka 565-0871, Japan; Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan.
³ Division of Cell Biology and Neuroscience, Department of Morphological and Physiological Sciences, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan.
⁴ Division of Cell Biology and Neuroscience, Department of Morphological and Physiological Sciences, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan; Research Center for Child Mental Development, University of Fukui, Fukui 910-1193, Japan.
⁵ Department of Anatomy and Neuroscience, Hyogo College of Medicine, Hyogo 663-8501, Japan.
⁶ Division of Cell Biology and Neuroscience, Department of Morphological and Physiological Sciences, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan; United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Osaka 565-0871, Japan; Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan; Research Center for Child Mental Development, University of Fukui, Fukui 910-1193, Japan. Electronic address: makosato@anat2.med.osaka-u.ac.jp.

PMID: 26655467
DOI: 10.1016/j.neulet.2015.11.049

Abstract

The callosal connections between the two hemispheres of the neocortex are altered in certain psychiatric disorders including schizophrenia. However, how and why the callosal connection is impaired in patients suffering from psychiatric diseases remain unclear. Filamin A interacting protein (FILIP), whose alteration through mutation relates to schizophrenic pathogenesis, binds to actin-binding proteins and controls neurotransmission. Because cortical excitatory neurons, including callosal projection neurons, migrate to the cortical plate during development, with the actin-binding proteins playing crucial roles during migration, we evaluated whether FILIP is involved in the development of the callosal projection neurons by histological analysis of Filip-knockout mice. The positioning of the callosal projection neurons, especially those expressing Plxnd1, in the superficial layer of the cortex is disturbed in these mice, which suggests that FILIP is a key molecule that links callosal projections to the pathogenesis of brain disorders.

Keywords: Callosal projection neuron; Cortical layer formation; FILIP; Knockout mouse; Neuronal migration; Schizophrenia.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Carrier Proteins / genetics
Carrier Proteins / metabolism*
Cerebral Cortex / cytology*
Corpus Callosum / cytology*
Mice, Knockout
Neurons / physiology*

Substances

Carrier Proteins
FILIP protein, mouse