Non-coding RNAs as orchestrators of autophagic processes

J Mol Cell Cardiol. 2016 Jun:95:26-30. doi: 10.1016/j.yjmcc.2015.11.012. Epub 2015 Dec 2.

Abstract

Autophagy is an important quality control mechanism present in all cells to maintain their cellular homeostasis. An imbalance in the autophagic process had been reported in numerous diseases including cardiovascular disease and is associated with serious consequences. Thus, knowledge of key regulators of cardiac autophagy is helpful to regain a balanced autophagic activity and to maintain healthy myocardial function. In this review we summarize all microRNAs which had been reported to regulate cardiac autophagy to date. In addition, we discuss long noncoding RNAs and circular RNAs as potential modulators of autophagy. Altering non-coding RNAs in-vivo by novel therapeutics offers a promising approach to treat autophagy-related diseases.

Keywords: Apoptosis; Atg; Autophagy; Hypertrophy; MicroRNA; mTOR.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Autophagosomes / metabolism
  • Autophagy / genetics*
  • Biological Transport
  • Cardiomegaly / genetics
  • Cardiomegaly / metabolism
  • Cardiomegaly / pathology
  • Gene Expression Regulation*
  • Humans
  • Myocardium / metabolism*
  • Myocytes, Cardiac / metabolism
  • RNA, Long Noncoding / genetics*
  • RNA, Long Noncoding / metabolism

Substances

  • RNA, Long Noncoding