Meta-analysis of downregulated E-cadherin as a poor prognostic biomarker for cervical cancer

Future Oncol. 2016 Mar;12(5):715-26. doi: 10.2217/fon.15.332. Epub 2015 Dec 11.

Abstract

Aim: This meta-analysis was conducted to evaluate the diagnostic and prognostic functions of E-cadherin expression in cervical cancer.

Methods: PubMed and other databases were searched for articles associated with E-cadherin and cervical cancer. These articles were published before June 2015 and written in English or Chinese. Random-effects model was used to pool odds ratios on the heterogeneity test in the meta-analysis.

Results: All of 20 studies were analyzed, in which 522 (42.6%) subjects exhibited reduced E-cadherin expression. Evaluation of clinicopathologic features showed that the downregulation of E-cadherin was related to the overall survival, clinicopathological parameters and age.

Conclusion: Downregulation of E-cadherin in cervical cancer patients showed poor overall survival. Therefore, E-cadherinmay be a metastasis-suppressor gene in cervical cancer.

Keywords: E-cadherin; biomarker; cervical cancer; meta-analysis; prognosis.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biomarkers
  • Cadherins / genetics*
  • Down-Regulation
  • Female
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Neoplasm Staging
  • Odds Ratio
  • Prognosis
  • Publication Bias
  • Uterine Cervical Neoplasms / genetics*
  • Uterine Cervical Neoplasms / mortality*
  • Uterine Cervical Neoplasms / pathology

Substances

  • Biomarkers
  • Cadherins