CuAAC: An Efficient Click Chemistry Reaction on Solid Phase

ACS Comb Sci. 2016 Jan 11;18(1):1-14. doi: 10.1021/acscombsci.5b00087. Epub 2015 Dec 21.

Abstract

Click chemistry is an approach that uses efficient and reliable reactions, such as Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC), to bind two molecular building blocks. CuAAC has broad applications in medicinal chemistry and other fields of chemistry. This review describes the general features and applications of CuAAC in solid-phase synthesis (CuAAC-SP), highlighting the suitability of this kind of reaction for peptides, nucleotides, small molecules, supramolecular structures, and polymers, among others. This versatile reaction is expected to become pivotal for meeting future challenges in solid-phase chemistry.

Keywords: Click Chemistry; CuAAC; alkyne; azide; solid-phase.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alkynes / chemical synthesis
  • Alkynes / chemistry
  • Azides / chemical synthesis
  • Azides / chemistry
  • Catalysis
  • Click Chemistry / economics
  • Click Chemistry / methods*
  • Copper / chemistry
  • Cycloaddition Reaction / economics
  • Cycloaddition Reaction / methods
  • Nucleotides / chemical synthesis
  • Nucleotides / chemistry
  • Peptides / chemical synthesis
  • Peptides / chemistry
  • Polymers / chemical synthesis
  • Polymers / chemistry
  • Small Molecule Libraries / chemical synthesis
  • Small Molecule Libraries / chemistry
  • Solid-Phase Synthesis Techniques / economics
  • Solid-Phase Synthesis Techniques / methods*

Substances

  • Alkynes
  • Azides
  • Nucleotides
  • Peptides
  • Polymers
  • Small Molecule Libraries
  • Copper