Analysis of human papillomavirus 16 variants and risk for cervical cancer in Chinese population

Virology. 2016 Jan 15:488:156-61. doi: 10.1016/j.virol.2015.11.016. Epub 2015 Nov 30.

Abstract

HPV16 is the most carcinogenic HPV type, but only a minority of HPV16 infections progress to cancer. Intratype genetic variants of HPV16 have been suggested to confer differential carcinogenicity. To investigate risk implications of HPV16 variants among Chinese women, a case-control study was conducted with 298 cervical cancer patients and 85 controls (all HPV16-positive). HPV16 isolates were predominantly of the A variant lineage, and variants of A4 (previously named "Asian") sublineage were common. A4/Asian variants were significantly associated with increased risk of cervical cancer compared to A1-3 (OR=1.72, 95% CI=1.04-2.85). Furthermore, a meta-analysis including 703 cases and 323 controls from East Asia confirmed the association (OR=2.82, 95% CI=1.44-5.52). In conclusion, A4 variants appear to predict higher risk of cervical cancer among HPV16-positive women, which may provide clues to the genetic basis of differences in the carcinogenicity of HPV16 variants.

Keywords: Case-control study; Cervical cancer; Human papillomavirus 16; Meta-analysis; Variant.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Asian People
  • Case-Control Studies
  • China / epidemiology
  • Female
  • Genetic Variation
  • Genotype*
  • Genotyping Techniques
  • Human papillomavirus 16 / classification*
  • Human papillomavirus 16 / genetics*
  • Human papillomavirus 16 / isolation & purification
  • Humans
  • Middle Aged
  • Molecular Epidemiology
  • Papillomavirus Infections / complications*
  • Papillomavirus Infections / epidemiology
  • Papillomavirus Infections / virology*
  • Risk Assessment
  • Uterine Cervical Neoplasms / epidemiology*
  • Uterine Cervical Neoplasms / virology*