Suspended Planar-Array Chips for Molecular Multiplexing at the Microscale

Adv Mater. 2016 Feb 17;28(7):1449-54. doi: 10.1002/adma.201504164. Epub 2015 Dec 9.

Abstract

A novel suspended planar-array chips technology is described, which effectively allows molecular multiplexing using a single suspended chip to analyze extraordinarily small volumes. The suspended chips are fabricated by combining silicon-based technology and polymer-pen lithography, obtaining increased molecular pattern flexibility, and improving miniaturization and parallel production. The chip miniaturization is so dramatic that it permits the intracellular analysis of living cells.

Keywords: chip-in-a-cell; planar-arrays; silicon chips; single-cell analysis; suspended-arrays.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • HeLa Cells
  • Humans
  • Lab-On-A-Chip Devices*
  • Polymers / chemistry
  • Printing

Substances

  • Polymers