Methods in renal research: kidney transplantation in the rat

Nephrology (Carlton). 2016 Jun;21(6):451-6. doi: 10.1111/nep.12697.

Abstract

Kidney transplantation in small animals has been crucial in the development of anti-rejection therapies. While there is no substitute for a skilled microsurgeon, there are many aspects of the transplant procedure that can be modified to optimize the reproducibility and utility of the technique. This article provides a detailed description, including video recording, of orthotopic kidney transplantation in the rat. The key variables in the technique are also discussed.

Keywords: arterial anastomosis; microsurgery; ureteric stent; venous anastomosis; video film.

Publication types

  • Review
  • Video-Audio Media

MeSH terms

  • Acute Disease
  • Animals
  • Biomedical Research / methods*
  • Disease Models, Animal
  • Graft Rejection / immunology*
  • Graft Rejection / prevention & control
  • Graft Survival
  • Kidney Transplantation / adverse effects*
  • Male
  • Nephrology / methods*
  • Rats, Inbred Lew
  • Species Specificity