Radical-mediated ring contraction in the biosynthesis of 7-deazapurines

Vahe Bandarian; Catherine L Drennan

doi:10.1016/j.sbi.2015.11.005

Radical-mediated ring contraction in the biosynthesis of 7-deazapurines

Curr Opin Struct Biol. 2015 Dec:35:116-24. doi: 10.1016/j.sbi.2015.11.005. Epub 2015 Nov 28.

Authors

Vahe Bandarian¹, Catherine L Drennan²

Affiliations

¹ Department of Chemistry, University of Utah, Salt Lake City, UT 84112, United States. Electronic address: vahe@chem.utah.edu.
² Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, United States; Department of Chemistry, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, United States.

Abstract

Pyrrolopyrimidine containing natural products are widely distributed in Nature. The biosynthesis of the 7-deazapurine moiety that is common to all pyrrolopyrimidines entails multiple steps, one of which is a complex radical-mediated ring contraction reaction catalyzed by CDG synthase. Herein we review the biosynthetic pathways of deazapurines, focusing on the biochemical and structural insights into CDG synthase.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Biocatalysis
Free Radicals / chemistry
Ligases / metabolism
Purines / biosynthesis*
Purines / chemistry*

Substances

7-deazapurine
Free Radicals
Purines
Ligases

Abstract

Publication types

MeSH terms

Substances

Grants and funding