Enhanced Systemic Bioavailability of Curcumin Through Transmucosal Administration of a Novel Microgranular Formulation

Brian Latimer; Oleksandr Ekshyyan; Neil Nathan; Tara Moore-Medlin; Xiaohua Rong; Xiaohui Ma; Alok Khandelwal; Hunter T Christy; Fleurette Abreo; Gloria McClure; John A Vanchiere; Gloria Caldito; Tammy Dugas; Kenneth McMartin; Timothy Lian; Vikas Mehta; Cherie-Ann O Nathan

Enhanced Systemic Bioavailability of Curcumin Through Transmucosal Administration of a Novel Microgranular Formulation

Anticancer Res. 2015 Dec;35(12):6411-8.

Authors

Brian Latimer¹, Oleksandr Ekshyyan², Neil Nathan¹, Tara Moore-Medlin², Xiaohua Rong², Xiaohui Ma², Alok Khandelwal², Hunter T Christy³, Fleurette Abreo⁴, Gloria McClure⁵, John A Vanchiere⁵, Gloria Caldito⁶, Tammy Dugas⁷, Kenneth McMartin⁸, Timothy Lian², Vikas Mehta², Cherie-Ann O Nathan⁹

Affiliations

¹ Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, LA, U.S.A. Department of Pharmacology, Toxicology and Neuroscience, Louisiana State University Health Sciences Center, Shreveport, LA, U.S.A.
² Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, LA, U.S.A. Department of Otolaryngology-Head and Neck Surgery, Louisiana State University Health Sciences Center, Shreveport, LA, U.S.A.
³ Department of Otolaryngology-Head and Neck Surgery, Louisiana State University Health Sciences Center, Shreveport, LA, U.S.A.
⁴ Department of Pathology, Louisiana State University Health Sciences Center, Shreveport, LA, U.S.A.
⁵ Department of Pediatrics, Louisiana State University Health Sciences Center, Shreveport, LA, U.S.A.
⁶ Department of Biometry, Louisiana State University Health Sciences Center, Shreveport, LA, U.S.A.
⁷ Department of Comparative Biomedical Sciences, Louisiana State University School of Veterinary Medicine, Baton Rouge, LA, U.S.A.
⁸ Department of Pharmacology, Toxicology and Neuroscience, Louisiana State University Health Sciences Center, Shreveport, LA, U.S.A.
⁹ Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, LA, U.S.A. Department of Otolaryngology-Head and Neck Surgery, Louisiana State University Health Sciences Center, Shreveport, LA, U.S.A. cnatha@lsuhsc.edu.

PMID: 26637850

Abstract

Background/aim: Curcumin is a promising nutraceutical for chemoprevention of head and neck squamous cell carcinoma (HNSCC). Capsular formulations of curcumin demonstrate low systemic bioavailability. We aimed to determine if curcumin levels were higher in healthy volunteers and cancer patients with microgranular curcumin that allows for transmucosal absorption and identify a consistent biomarker.

Patients and methods: Eight healthy volunteers and 15 HNSCC patients completed the trials. Serum levels of curcumin were measured by HPLC. Biological activity of curcumin was assessed with Multiplex Immunoassay and immunohistochemistry.

Results: We achieved higher serum levels of curcumin compared to trials using capsular formulation. In cancer patients a significant decrease in expression of fibroblast growth factor-2 (FGF-2) in post-biopsy samples and decreased serum levels of FGF-2, granulocyte macrophage colony-stimulating factor (GM-CSF) and interleukin-17 (IL-17) (p<0.05) was observed.

Conclusion: Transmucosal administration of microgranular curcumin leads to enhanced curcumin bioavailability that is associated with significant biological effects.

Keywords: Curcumin; bioavailability; head and neck squamous cell carcinoma; microgranules.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Administration, Mucosal
Adult
Aged
Biological Availability
Case-Control Studies
Curcumin / administration & dosage*
Curcumin / pharmacokinetics*
Female
Humans
Male
Middle Aged
Young Adult

Substances

Curcumin

Grants and funding

R21CA137545/CA/NCI NIH HHS/United States