Two New Flavonol Glycosides from Polygala sibirica L. var megalopha Fr

Molecules. 2015 Dec 2;20(12):21494-500. doi: 10.3390/molecules201219775.

Abstract

Two new flavonol glycosides, named polygalin H (1) and polygalin I (2), as well as the known compound polygalin D (3), were isolated from the whole plant of Polygala sibirica L. var megalopha Fr. Their structures were elucidated on the basis of spectroscopic data analysis. These flavonol glycosides exhibited strong inhibitory activities against xanthine oxidase in vitro. Their half-maximal inhibitory concentrations (IC50) were calculated, which were 9.48, 8.31, 16.00 μM, respectively.

Keywords: Polygala sibirica; Polygalaceae; flavonol glycosides; inhibition of xanthine oxidase.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Enzyme Inhibitors / isolation & purification
  • Enzyme Inhibitors / pharmacology*
  • Flavonols / isolation & purification*
  • Flavonols / pharmacology
  • Glycosides / isolation & purification*
  • In Vitro Techniques
  • Molecular Structure
  • Plant Extracts / pharmacology*
  • Polygala / chemistry*
  • Xanthine Oxidase / antagonists & inhibitors*

Substances

  • Enzyme Inhibitors
  • Flavonols
  • Glycosides
  • Plant Extracts
  • polygalin H
  • polygalin I
  • Xanthine Oxidase