Protein Adsorption Switch Constructed by a Pillar[5]arene-Based Host-Guest Interaction

Chemistry. 2016 Jan 18;22(3):941-5. doi: 10.1002/chem.201504076. Epub 2015 Dec 3.

Abstract

The interfacial properties of solid substrates are of importance for protein adsorption. Herein, we report a reversible protein adsorption switch based on the host-guest interaction of the butoxy pillar[5]arene and adipic acid. By the detector of the contact angle (CA), atomic force microscopy (AFM), and luminoscope on the silicon substrate, the intelligent protein switch exhibits excellent adsorptivity for BSA and switch performance by pH regulation.

Keywords: bovine serum albumin; host-guest systems; pH reversible switch; pillar[5]arene; proteins.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adsorption
  • Calixarenes
  • Microscopy, Atomic Force
  • Models, Molecular
  • Proteins / chemistry*
  • Proteins / metabolism*
  • Quaternary Ammonium Compounds / chemistry*
  • Serum Albumin, Bovine / chemistry*
  • Surface Properties

Substances

  • Proteins
  • Quaternary Ammonium Compounds
  • pillar(5)arene
  • Calixarenes
  • Serum Albumin, Bovine