Is urine intercellular adhesion molecule-1 a marker of renal disorder in children with ureteropelvic junction obstruction?

Biomarkers. 2016;21(2):123-8. doi: 10.3109/1354750X.2015.1118543. Epub 2015 Dec 3.

Abstract

Aim: We aimed to investigate whether urine intercellular adhesion molecule-1 (ICAM-1) might serve as a marker of renal disorder in children with ureteropelvic junction obstruction.

Material and methods: Twenty-nine children with severe hydronephrosis (HN) were compared with 23 participants with mild HN and with 19 healthy peers.

Results: Urine ICAM-1/uCre levels were significantly higher in HN children than healthy controls (P<0.01), and in severe HN when compared with mild HN (p<0.05).

Conclusions: It seemed to us that uICAM-1 is a biomarker of renal disorder, and might have the potential to predict which patients will require surgery.

Keywords: Hydronephrosis; marker; renal disorder.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analysis of Variance
  • Biomarkers / urine*
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Hydronephrosis / diagnosis
  • Hydronephrosis / urine
  • Infant
  • Intercellular Adhesion Molecule-1 / urine*
  • Kidney Diseases / diagnosis
  • Kidney Diseases / urine*
  • Male
  • Prognosis
  • ROC Curve
  • Severity of Illness Index
  • Ureteral Obstruction / diagnosis
  • Ureteral Obstruction / urine*

Substances

  • Biomarkers
  • Intercellular Adhesion Molecule-1