Anticancer Potencies of Pt(II) - and Pd(II)-linked M2L4 Coordination Capsules with Improved Selectivity

Chem Asian J. 2016 Feb 18;11(4):474-7. doi: 10.1002/asia.201501238. Epub 2015 Dec 23.

Abstract

Pt(II) - and Pd(II)-linked M2 L4 coordination capsules, providing a confined cavity encircled by polyaromatic frameworks, exhibit anticancer activities superior to cisplatin against two types of leukemic cells (HL-60 and SKW-3) and pronounced toxicity against cisplatin-resistant cells (HL-60/CDDP). Notably, the cytotoxic selectivities of the Pt(II) and Pd(II) capsules toward cancerous cells are up to 5.3-fold higher than that of cisplatin, as estimated through the non-malignant/malignant-cells toxicity ratio employing normal kidney cells (HEK-293). In addition, the anticancer activity of the coordination capsules can be easily altered upon encapsulation of organic guest molecules.

Keywords: anticancer activity; cancer; cisplatin; coordination capsules; encapsulation; platinum ion.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anthracenes / chemistry
  • Anthracenes / pharmacology
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacokinetics*
  • Capsules
  • Cell Line, Tumor
  • Cisplatin / pharmacology
  • Coordination Complexes / chemistry
  • Coordination Complexes / pharmacology
  • Drug Resistance, Neoplasm
  • HEK293 Cells
  • Humans
  • Leukemia / drug therapy
  • Models, Molecular
  • Organoplatinum Compounds / chemistry*
  • Organoplatinum Compounds / pharmacology*
  • Palladium / chemistry*
  • Palladium / pharmacology*

Substances

  • Anthracenes
  • Antineoplastic Agents
  • Capsules
  • Coordination Complexes
  • Organoplatinum Compounds
  • Palladium
  • anthracene
  • Cisplatin