The bovine enzootic bronchopneumonia is a multi-causal determined and by several factors triggered general factor-disease. Since therapy is mostly disappointing, prophylaxis is the most advantageous way to curb the disease. Vaccination with combined vaccines has been very promising. A cost-benefit-analysis shows that the decrease in morbidity from 72% to 7.3% and in mortality from 5.1 to 0.9% results in a benefit-cost-relation between 5 to 1 and 7 to 1. That means preventive vaccination against crowding associated enzootic bronchopneumonia saves approximately 180,- DM per animal and 250,- DM per animal in case of seasonal enzootic bronchopneumonia.