Defective sirtuin-1 increases IL-4 expression through acetylation of GATA-3 in patients with severe asthma

J Allergy Clin Immunol. 2016 May;137(5):1595-1597.e7. doi: 10.1016/j.jaci.2015.10.013. Epub 2015 Nov 25.

Authors

Thomas Colley¹, Nicolas Mercado¹, Yuichi Kunori¹, Christopher Brightling², Pankaj K Bhavsar¹, Peter J Barnes¹, Kazuhiro Ito³

Affiliations

¹ Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom.
² Respiratory Medicine, Glenfield Hospital, University of Leicester, Leicester, United Kingdom.
³ Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom. Electronic address: k.ito@imperial.ac.uk.

PMID: 26627546
DOI: 10.1016/j.jaci.2015.10.013

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Acetylation
Adult
Asthma / blood
Asthma / diagnosis
Asthma / immunology*
Biomarkers / blood
Case-Control Studies
Female
GATA3 Transcription Factor / blood*
Humans
Interleukin-4 / blood*
Male
Severity of Illness Index
Sirtuin 1 / blood*

Substances

Biomarkers
GATA3 Transcription Factor
GATA3 protein, human
IL4 protein, human
Interleukin-4
SIRT1 protein, human
Sirtuin 1