Association of Apolipoprotein A1 Gene Polymorphisms with Serum Lipid Spectrum in Adolescents in East Siberia

Bull Exp Biol Med. 2015 Dec;160(2):267-70. doi: 10.1007/s10517-015-3146-8.

Abstract

We studied the incidence of genotypes of polymorphic alleles (-75)G>A and (+83)C>T of apolipoprotein A1 gene in healthy Russian adolescents, residents of East Siberia. Genotyping was carried out by PCR with subsequent restriction fragment length polymorphism analysis. The incidence of allele (-75)A was 22.5%, of allele (+83)T - 7.3%. Association of allele (-75) A with high blood cholesterol level was revealed.

Keywords: Russians; adolescents; apolipoprotein A1; genotype; lipids.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Alleles
  • Apolipoprotein A-I / genetics*
  • Child
  • Cholesterol / blood
  • Female
  • Genotype
  • Humans
  • Lipids / blood*
  • Male
  • Polymorphism, Genetic / genetics*
  • Siberia

Substances

  • Apolipoprotein A-I
  • Lipids
  • Cholesterol