The presence or severity of pulmonary hypertension does not affect outcomes for single-lung transplantation

Thorax. 2016 May;71(5):478-80. doi: 10.1136/thoraxjnl-2015-207354. Epub 2015 Nov 30.

Abstract

Advanced lung disease (ALD) that requires lung transplantation (LTX) is frequently associated with pulmonary hypertension (PH). Whether the presence of PH significantly affects the outcomes following single-lung transplantation (SLT) remains controversial. Therefore, we retrospectively examined the outcomes of 279 consecutive SLT recipients transplanted at our centre, and the patients were split into four groups based on their mean pulmonary artery pressure values. Outcomes, including long-term survival and primary graft dysfunction, did not differ significantly for patients with versus without PH, even when PH was severe. We suggest that SLT can be performed safely in patients with ALD-associated PH.

Keywords: Lung Transplantation; Thoracic Surgery.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Graft Rejection / prevention & control
  • Humans
  • Hypertension, Pulmonary / diagnosis
  • Hypertension, Pulmonary / mortality
  • Hypertension, Pulmonary / physiopathology
  • Hypertension, Pulmonary / surgery*
  • Kaplan-Meier Estimate
  • Lung Diseases / surgery
  • Lung Transplantation* / methods
  • Lung Transplantation* / mortality
  • Retrospective Studies
  • Severity of Illness Index
  • Treatment Outcome