A case report on intermediate-grade malignant meningeal melanocytoma with elevated cell proliferation index

Int J Clin Exp Pathol. 2015 Sep 1;8(9):11698-703. eCollection 2015.

Abstract

Meningeal melanocytoma is a kind of extremely rare pigmented tumor of the central nervous system, which often occurs in the groove around the base of the brain and spinal pia mater. Age of onset is 40 to 50 years old, mostly presenting a benign course of disease and the prognosis is good. Case reports of partial invasion or metastasis from lesions are even rarer. This report described a case of 56-year-old meningeal melanoma patient with partial skull and muscle invasion at the lantooccipital transition zone. Intraoperative histological examination showed moderate malignancy and Ki-67 index was 10%.

Keywords: Meningeal melanocytoma; neurosurgery; tumor.

Publication types

  • Case Reports

MeSH terms

  • Biomarkers, Tumor / analysis
  • Cell Proliferation
  • Humans
  • Ki-67 Antigen / analysis
  • Male
  • Melanoma / pathology*
  • Meningeal Neoplasms / pathology*
  • Middle Aged
  • Mitotic Index
  • Neoplasm Invasiveness / pathology*

Substances

  • Biomarkers, Tumor
  • Ki-67 Antigen