Potential of neuropeptide Y for preventing or treating post-traumatic stress disorder

Esther L Sabban; Lishay G Alaluf; Lidia I Serova

doi:10.1016/j.npep.2015.11.004

Potential of neuropeptide Y for preventing or treating post-traumatic stress disorder

Neuropeptides. 2016 Apr:56:19-24. doi: 10.1016/j.npep.2015.11.004. Epub 2015 Nov 12.

Authors

Esther L Sabban¹, Lishay G Alaluf², Lidia I Serova²

Affiliations

¹ Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, United States. Electronic address: sabban@nymc.edu.
² Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, United States.

PMID: 26617395
DOI: 10.1016/j.npep.2015.11.004

Abstract

There is extensive evidence that NPY in the brain can modulate the responses to stress and play a critical role in resistance to, or recovery from, harmful effects of stress. Development of PTSD and comorbid depression following exposure to traumatic stress are associated with low NPY. This review discusses putative mechanisms for NPY's anti-stress actions. Recent preclinical data indicating potential for intranasal delivery of NPY to brain as a promising non-invasive strategy to prevent a variety of neuroendocrine, molecular and behavioral impairments in PTSD model are summarized.

Keywords: Depression; Intranasal; PTSD; Resilience; Single prolonged stress.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Animals
Brain / drug effects
Brain / metabolism*
Humans
Neuropeptide Y / administration & dosage
Neuropeptide Y / metabolism*
Stress Disorders, Post-Traumatic / metabolism*
Stress Disorders, Post-Traumatic / prevention & control*

Substances

Neuropeptide Y