Characterization of omega-3 tablets

Tina Lien Vestland; Øyvind Jacobsen; Sverre Arne Sande; Astrid Hilde Myrset; Jo Klaveness

doi:10.1016/j.foodchem.2015.10.142

Characterization of omega-3 tablets

Food Chem. 2016 Apr 15;197(Pt A):496-502. doi: 10.1016/j.foodchem.2015.10.142. Epub 2015 Oct 30.

Authors

Tina Lien Vestland¹, Øyvind Jacobsen², Sverre Arne Sande³, Astrid Hilde Myrset⁴, Jo Klaveness⁵

Affiliations

¹ Omegatri AS, P.O. Box 4849 Nydalen, 0422 Oslo, Norway; School of Pharmacy, University of Oslo, P.O. Box 1068 Blindern, 0316 Oslo, Norway. Electronic address: tina.lien.vestland@omegatri.no.
² Department of Chemistry, University of Oslo, P.O. Box 1033 Blindern, 0315 Oslo, Norway.
³ School of Pharmacy, University of Oslo, P.O. Box 1068 Blindern, 0316 Oslo, Norway.
⁴ Tåsen Terrasse 4A, 0873 Oslo, Norway.
⁵ Omegatri AS, P.O. Box 4849 Nydalen, 0422 Oslo, Norway; School of Pharmacy, University of Oslo, P.O. Box 1068 Blindern, 0316 Oslo, Norway.

PMID: 26616980
DOI: 10.1016/j.foodchem.2015.10.142

Abstract

Omega-3 nutraceuticals are extensively used as health supplements worldwide. Various administration forms for delivery of omega-3 are available. However, the niche omega-3 tablets have so far remained unexplored. In this work tablets containing 25-40% (w/w) omega-3 oil as triglycerides or ethyl esters were prepared utilizing a direct compaction grade powder with β-cyclodextrin as encapsulating agent. It was found that powders with up to 35% (w/w) triglyceride oil and 30% (w/w) ethyl ester oil, respectively, can be directly compressed into tablets of excellent quality. Physical properties of omega-3 containing powders and tablets are described. The powder X-ray diffractograms of the powders and crushed tablets show evidence of the formation of new crystalline phases not present in β-cyclodextrin. In addition, (1)H NMR data suggest that the ethyl esters form inclusion complexes with β-cyclodextrin. Compaction of other, commercially available, omega-3 powders was performed as a comparison and deemed unsuccessful.

Keywords: Cyclodextrin; DHA; EPA; Fish oil; Omega-3; Powder; Tablets.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Dietary Supplements / analysis*
Fatty Acids, Omega-3 / analysis*
Powders / chemistry
Tablets / chemistry
Triglycerides / analysis
beta-Cyclodextrins / analysis

Substances

Fatty Acids, Omega-3
Powders
Tablets
Triglycerides
beta-Cyclodextrins
betadex