Frontotemporal Dementia

Roger E Kelley; Ramy El-Khoury

doi:10.1016/j.ncl.2015.08.007

Frontotemporal Dementia

Neurol Clin. 2016 Feb;34(1):171-81. doi: 10.1016/j.ncl.2015.08.007.

Authors

Roger E Kelley¹, Ramy El-Khoury²

Affiliations

¹ Department of Neurology, Tulane University School of Medicine, 1430 Tulane Avenue, 8065, New Orleans, LA 70112, USA. Electronic address: rkelley2@tulane.edu.
² Department of Neurology, Tulane University School of Medicine, 1430 Tulane Avenue, 8065, New Orleans, LA 70112, USA.

Abstract

Frontotemporal dementia (FTD) is a not-uncommon explanation for progressive cognitive deficit in patients who often have a genetic susceptibility for such a neurodegenerative process. However, FTD does not seem to identify one particular pathogenetic mechanism but rather a spectrum of pathologies with particular predilection for the frontal and temporal lobes of the brain. There have been various subcategorizations of this form of dementia that have a tendency to be of earlier onset than typical Alzheimer disease and heralded by behavioral or communication manifestations. There is a behavioral variant and a language variant, referred to as primary progressive aphasia.

Keywords: Abulia; Aphasia neurodegenerative disorder; Behavioral disturbance; Dementia; Disinhibition; Impulsivity; Inattention.

Publication types

Review

MeSH terms

Aphasia, Primary Progressive / diagnosis*
Aphasia, Primary Progressive / pathology
Brain / pathology*
Frontotemporal Dementia / diagnosis*
Frontotemporal Dementia / pathology
Humans
Neuropsychological Tests

Abstract

Publication types

MeSH terms

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