MR Imaging Biomarkers in Oncology Clinical Trials

Richard G Abramson; Lori R Arlinghaus; Adrienne N Dula; C Chad Quarles; Ashley M Stokes; Jared A Weis; Jennifer G Whisenant; Eduard Y Chekmenev; Igor Zhukov; Jason M Williams; Thomas E Yankeelov

doi:10.1016/j.mric.2015.08.002

MR Imaging Biomarkers in Oncology Clinical Trials

Magn Reson Imaging Clin N Am. 2016 Feb;24(1):11-29. doi: 10.1016/j.mric.2015.08.002.

Affiliations

¹ Department of Radiology and Radiological Sciences, Institute of Imaging Science, Vanderbilt University, VUIIS 1161 21st Avenue South, AA 1105 MCN, Nashville, TN 37232-2310, USA.
² Department of Radiology and Radiological Sciences, Vanderbilt University, 1161 21st Avenue South, AA 1105 MCN, Nashville, TN 37232-2310, USA.
³ Department of Radiology and Radiological Sciences, Institute of Imaging Science, Vanderbilt University, VUIIS 1161 21st Avenue South, AA 1105 MCN, Nashville, TN 37232-2310, USA; Department of Biomedical Engineering, Institute of Imaging Science, Vanderbilt University, VUIIS 1161 21st Avenue South, AA 1105 MCN, Nashville, TN 37232-2310, USA; Department of Cancer Biology, Institute of Imaging Science, Vanderbilt University, 1161 21st Avenue South, AA 1105 MCN, Nashville, TN 37232-2310, USA.
⁴ Department of Biomedical Engineering, Vanderbilt University, VUIIS 1161 21st Avenue South, AA 1105 MCN, Nashville, TN 37232-2310, USA.
⁵ Department of Radiology and Radiological Sciences, Institute of Imaging Science, Vanderbilt University, VUIIS 1161 21st Avenue South, AA 1105 MCN, Nashville, TN 37232-2310, USA; Department of Biomedical Engineering, Institute of Imaging Science, Vanderbilt University, VUIIS 1161 21st Avenue South, AA 1105 MCN, Nashville, TN 37232-2310, USA; Department of Biochemistry, Institute of Imaging Science, Vanderbilt University, 1161 21st Avenue South, AA 1105 MCN, Nashville, TN 37232-2310, USA.
⁶ National Research Nuclear University MEPhI, Kashirskoye highway, 31, Moscow 115409, Russia.
⁷ Department of Radiology and Radiological Sciences, Institute of Imaging Science, Vanderbilt University, 1161 21st Avenue South, AA 1105 MCN, Nashville, TN 37232-2310, USA.
⁸ Department of Radiology and Radiological Sciences, Institute of Imaging Science, Vanderbilt University, VUIIS 1161 21st Avenue South, AA 1105 MCN, Nashville, TN 37232-2310, USA; Department of Biomedical Engineering, Institute of Imaging Science, Vanderbilt University, VUIIS 1161 21st Avenue South, AA 1105 MCN, Nashville, TN 37232-2310, USA; Department of Cancer Biology, Institute of Imaging Science, Vanderbilt University, 1161 21st Avenue South, AA 1105 MCN, Nashville, TN 37232-2310, USA; Department of Physics, Institute of Imaging Science, Vanderbilt University, VUIIS 1161 21st Avenue South, AA 1105 MCN, Nashville, TN 37232-2310, USA. Electronic address: thomas.yankeelov@vanderbilt.edu.

Abstract

The authors discuss eight areas of quantitative MR imaging that are currently used (RECIST, DCE-MR imaging, DSC-MR imaging, diffusion MR imaging) in clinical trials or emerging (CEST, elastography, hyperpolarized MR imaging, multiparameter MR imaging) as promising techniques in diagnosing cancer and assessing or predicting response of cancer to therapy. Illustrative applications of the techniques in the clinical setting are summarized before describing the current limitations of the methods.

Keywords: CEST; DCE-MR imaging; DSC-MR imaging; Diffusion; Elastography; Hyperpolarized; Multiparametric.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Biomarkers, Tumor / metabolism*
Clinical Trials as Topic
Humans
Magnetic Resonance Imaging / trends*
Magnetic Resonance Spectroscopy / methods*
Medical Oncology / trends
Molecular Imaging / trends*
Neoplasms / diagnosis*
Neoplasms / metabolism
Neoplasms / therapy*
Outcome Assessment, Health Care / trends

Substances

Biomarkers, Tumor

MR Imaging Biomarkers in Oncology Clinical Trials

Authors

Affiliations

Abstract

Publication types

MeSH terms

Substances

Grants and funding